The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans.

نویسندگان

D Matzinger

L Degen

J Drewe

J Meuli

R Duebendorfer

N Ruckstuhl

M D'Amato

L Rovati

C Beglinger

چکیده

BACKGROUND AND AIMS The mechanism of intraduodenal fat induced inhibition of food intake is still unclear. Therefore, we tested the ability of duodenal fatty acids to suppress food intake at a lunchtime meal; in addition, we were interested to test if these effects were mediated by cholecystokinin (CCK) A receptors. SUBJECTS AND METHODS Three sequential double blind, three period crossover studies were performed in 12 healthy males each: (1) subjects received intraduodenal fat with or without 120 mg of tetrahydrolipstatin, an inhibitor of gastrointestinal lipases, or saline; (2) volunteers received intraduodenal long chain fatty acids, medium chain fatty acids, or saline; (3) subjects received long chain fatty acids or saline together with concomitant intravenous infusions of saline or loxiglumide, a specific CCK-A receptor antagonist. The effect of these treatments on food intake and feelings of hunger was quantified. RESULTS Intraduodenal fat perfusion significantly (p<0.05) reduced calorie intake. Inhibition of fat hydrolysis abolished this effect. Only long chain fatty acids significantly (p<0.05) decreased calorie intake, whereas medium chain fatty acids were ineffective. Infusion of loxiglumide abolished the effect of long chain fatty acids. CONCLUSIONS Generation of long chain fatty acids through hydrolysis of fat is a critical step for fat induced inhibition of food intake; the signal is mediated via CCK-A receptors.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

P3: Food and Behavior: Long Chain Poly Unsaturated Fatty Acids and Anxiety

The anecdote "we are what we eat" in line with the doctrine of Hypocrates in 400 BC “Let food be thy medicine and medicine thy food” are vividly portray the importance of daily regimen in human health and body well-functioning. There is a growing body of evidence that suggests the relative intake of specific nutrients can have a profound effect on physiology of individuals...

متن کامل

P28: The Effects of Omega-3 and 6 Fatty Acids on Hippocampus and Learning

One of the most nervous system evolution are memory and learning in humans. Learning is a skill that enhances synaptic activity in the hippocampus of prefrontal cortex. In fact, basic passive learning is communication between the conditioned and Unconditioned stimulation. Passive learning involves three steps: habit, education and remember. According to the results of investigations, the hippoc...

متن کامل

I-7: Fatty Acids and Male Reproductive Function

Background Background: The fatty acid composition of the sperm membrane changes drastically during spermatogenesis and may be key to its function. Previous data has shown that intake of long chain poly-unsaturated fatty acids can change the fatty acid composition of tissues, including testes and sperm. However, whether these changes in composition translate into changes in semen quality or male...

متن کامل

Zooplankton and their protective effects on cardiovascular diseases

In the world-wide cardiovascular diseases are the most common. And mortallities are high. Many modifiable and non-modifiable risk factors for cardiovascular diseases have been identified. One of them is diets. In diet polyunsaturated fatty acids such omega-3 and omega-6 have protective effects on cardiovascular health. Polyunsaturated fatty acids are essentials for humans, have taken from foods...

متن کامل